Clinical Research

The first several studies below provide information on prevalence, complications and costs related to muscle atrophy and weakness post TKA/THA. The next three provide support for MEND in reducing muscle atrophy and weakness. We are now in a 4th randomized trial with Slocum (author of 2 of the 3 current studies) and are looking at changes at a cellular level. The final study was done on EAA supplementation and blood albumin and haemoglobin levels. MEND is a safe and effective intervention with significant positive implications for patient recovery, outcomes and hospital costs.
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  • Joint Replacement Healing
  • Joint Replacement Nutrition
  • Joint Replacement Recovery

INTRODUCTION: This study sought to determine the effect that malnutrition, defined as hypoalbuminemia, has on hip fracture patients treated with total hip arthroplasty (THA). Specifically, we evaluated: (1) demographics and perioperative data; (2) postoperative complications; and (3) re-operation rates. METHODS: The National Surgical Quality Improvement Program database was utilised to identify hip fracture patients who underwent THA from 2008 to 2015. Propensity scores...

One of the many studies looking at the atrophy that occurs from disuse and bed rest. A 2008 study by Jirikca also estimated a 12% loss in as little as a week (50% loss in 3 to 5 weeks). This study concludes: 1 week of bed rest substantially reduces skeletal muscle mass and lowers whole-body insulin sensitivity, without affecting mechanisms implicated in high-fat diet-induced insulin...

This is a study by Dr.'s Bridget Ellsworth and Atul Kamath looking at the prevalence of malnutrition and the associated complications in the total joint population: study link. Conclusions Hypoalbuminemia (albumin <3.5 g/dL) is a commonly used surrogate for malnutrition. Preoperative hypoalbuminemia is prevalent in patients undergoing elective TJA, including in obese patients. Malnutrition has been shown to be an independent risk...

Full study can be read here: Link Background There have been many efforts to find modifiable risk factors for venous thromboembolism (VTE) in the perioperative period of total knee arthroplasty (TKA), while no study has investigated the relationship between the muscle mass and deep vein thrombosis (DVT) or pulmonary embolism frequency following TKA. This study aimed to evaluate the relationship between muscle...

Results of a retrospective study by United BioSource and Eli Lilly on 43 thousand total hip patients. The full study can be seen here: Link Conclusions Among US patients undergoing THA, those with MAW had higher health care resource use and costs as compared to those without MAW. Commercially insured patients with MAW were also more likely to have any all-cause, as...

Published in the prestigious Journal of Applied Physiology by our partners at Slocum Orthopedics, this paper builds on the outcomes studies (which show that MEND enhances functional outcomes) and shows that our formulation increases muscle satellite cells pre-surgery and a more favorable inflammatory environment post surgery. In short, MEND promotes healing and better function. Full paper here: Link...

This enhanced study was performed by MDs at Slocum Orthopedics and Oregon University. We have enhanced our formulation to increase the level of certain key amino acids and are now conducting yet another study with Slocum. Essential Amino Acid Supplementation Mitigates Muscle Atrophy After Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial JBJS Open Access: June 28, 2018 - Volume 3 - Issue...

This is the original 2013 study with our partners Slocum Center for Orthopedics & Sports Medicine who we are currently performing another study with on our enhanced formulation that builds off of this research. We expect even better outcomes. Essential amino acid supplementation in patients following total knee arthroplasty Hans C. Dreyer,1 Lisa A. Strycker,2 Hilary A. Senesac,1 Austin D. Hocker,1 Keith Smolkowski,2 Steven N. Shah,3 andBrian A....

The study looks at the impact of supplementing with EAAs on blood albumin and haemoglobin levels. MEND contains 3x the level of EAAs per serving. (Study Link). Abstract Essential amino acids (EAAs) are nutritional substrates that promote body protein synthesis; thus we hypothesised that their supplementation may improve circulating albumin (Alb) and haemoglobin (Hb) in rehabilitative elderly patients following hip fractures (HF)....